摘要
参考Troost法检测了肝细胞癌(HCC)及其他肝脏占位性病变和疾病患者血清和组织中的α-L-岩藻糖甙酶(AFU)活性。结果表明:血清AFU活性测定对HCC诊断的敏感性和特异性分别为81.2％和83.3％。对甲胎蛋白阴性和早期HCC诊断敏感性亦分别达76.1％和70.8％。HCC组织及其癌周肝组织中AFU活性明显高于对照组近1倍,且与相应血清中的活性升高相一致(r=0.742,P<0.01)。提示AFU可能是HCC的新型生物学标记物,对HCC的诊断有重要价值。
α-L-fucosidas:-(AFU)activity was determined by referring to Troost's method in sera, liver tissues and lesions from patients with htpatocellular carcinoma (HCC), other liver space-occupying lesions (SOL)and diseases.The results showed that the sensitivity and specificity for the diagnosis of HCC were 81.2% and 83.3% respectively with the assay of serum AFU activity, and the sensitivities in the diagnosis of AFP-negative and early HCC were 76.1% and 70.8%, respectively.The AFU activity in the HCC tissues and their peri cancerous liver tissues was twice as much as controls, and consisted with their serum AFU activity (r= 0.742, P<0.01).It is suggested that AFU could be a new biologic marker of HCC and have an important value in the diagnosis of HCC.
出处
《第二军医大学学报》
CAS
CSCD
北大核心
1989年第3期216-221,共6页
Academic Journal of Second Military Medical University
关键词
肝肿瘤
甲胎蛋白
岩藻糖甙酶
AFU
hepatoma
a-L-fucosidase
diagnosis
a-fetoprotein
liver diseases
