摘要
我们曾经发现在利血平诱发胃溃疡的大鼠,其脑内的单胺类递质近乎耗竭,呋喃唑酮能完全对抗利血平诱发的胃溃疡。本实验观察到在应激性胃溃疡大鼠,其脑内的NE显著降低,呋喃唑酮能部分地对抗应激性溃疡。在消炎痛和幽门结扎引起的胃溃疡大鼠,不伴有脑内单胺类递质含量的改变,呋喃唑酮对这两种胃溃疡无效。这些结果提示,呋喃唑酮的抗溃疡作用与其抑制脑内MAO活性,从而提高单胺类递质含量、恢复其动态平衡有关。
Our previous work showed that, in the rats with reserpine-induced gastric ulcer, brain monoamines (NE, DA and 5-HT) were exhausted and furazolidone completely prevented such a gastric ulcer.The present study was carried out to observe brain monoamine contents and antiulcerogenic effects of furazolidone in other gastric ulcer modtls of rats.It was found that in the rats with gastric ulcer induced by restraint in water (21℃ for 18[h), brain NE content was significantly decreased.Furazolidone partially prevented this gastric ulcer and increased brain monoamines in these animals.In the rats with gastric ulcer induced by indomethacin or pyloric ligature, brain monoamines were unchanged and no effects of furazolidone were observed.These results suggest that the inhibitory effect of furazolidone on brain monoamine oxidase may be the mechanism of its antiulcerogenic action.
出处
《第二军医大学学报》
CAS
CSCD
北大核心
1989年第2期123-125,共3页
Academic Journal of Second Military Medical University
关键词
胃溃疡
单胺类递质
呋喃唑酮
动物
gastric ulcer
furazolidone
monoamines
disease models,animal
rats
