摘要
本试验用１２５Ｉ一ＵｄＲ释放试验，对４８例原发性肺癌患者及６６例健康体检者的外周血自然杀伤细胞活性进行观察，结果显示肺癌患者自然杀伤细胞活性（１８．８５％±１１．６９％）较健康对照（４１．９５％±１１．８７％）显著降低（Ｐ＜０．００１）。并与病变的进展及患者血清ＣＥＡ水平呈中度负相关（Ｒ＝－０．６２，Ｐ＜０．１）。吸烟对ＮＫ细胞活性的严重抑制（３２．３７％±１１．６７％），可能在肺癌发病学中起一定作用。
NK cell
activity of peripheral blood was detected by 125 I-UdR re-lease assay
in 48 patients with lung cancer and 66 health suhjects as control.
The serumCEA was measured by PIA simultanorsly. The blood NK cell
activity Of patients With lung cancer(l8.85 %±ll.69%) was
sig-niticantly lower than thatt of control group (41.95%±11.87%)P<0,
001.The results obtai-ned in lung cancer patients at different stages
were as follows:(1)Stage I, 9 cases(NK:28.41%土14.19%);(2) Stage
Ⅱ,10 cases (NK: 20.7l%±8.00%);(3) Stage Ⅲ, 18 case8(NK:15.51%土
8.85%);) StageⅣ, 9 cases(NK: 12.43% ±4.03%)A negtive relationship
wasfound between the NK activity and the CEA level(R=-0.62,P<0.1) or
the patients inadvance of lung cancer。 We suppose that the NK cell
activity may play a role in theprognosis of lung cancer。
出处
《癌症》
SCIE
CAS
CSCD
北大核心
1995年第2期94-96,共3页
Chinese Journal of Cancer
