摘要
测定了１０３例癌症病人和１１７例对照血清，外周血淋巴细胞以及２１例组织和癌旁正常组织腺苷脱氦酶（ＡＤＡ）的活性。结果表明：癌症组血清ＡＤＡ活性为２２．９±８．８３Ｕ／ｍｌ，对照组为１５．２１±５．６７Ｕ／ｍｌ，两者比较差异有非常显著性意义（ｔ＝７．５６，Ｐ＜０．０１）；癌症组淋巴细胞ＡＤＡ活性为３．９６±１，７４Ｕ／ｍｇｐｒｏｔｅｉｎ，对照组为７．３７±３．６５Ｕ／ｍｇｐｒｏｔｅｉｎ，两者比较差异有非常显著性意义（ｔ＝８．６５，Ｐ＜０．０１）；２１例癌组织ＡＤＡ活性为０．０９６±０．０５４Ｕ／ｍｇｐｒ－ｏｔｅｉｎ，癌旁正常组织为０．０４３±０．０３３Ｕ／ｍｇｐｒｏｔｅｉｎ，两者比较差异有非常显著性意义（ｔ＝０．８６，Ｐ＜０．０１）。提示：检测腺苷脱氨酶活性对观察癌症病人的疗效和预后有一定价值。
In this
paper, adenosine deaminase(ADA)has been measured in 103 cases of
patients with various typens of Cancer and117 cases of
controls.ADAactivity in serum of the patients with cancers(22.69±
8.83 U/ml)was much higher thanthose in the controls (15.2l±
5.67U/ml)(t=7.56,P<0.0).ADA activity in lymphocytesof cancer
groups(3.96± l.74U/mg protein)was found to be significantly lower
thanthose in the controls(7.37±3.65 U/mg protein)(t=8.65,P<0.0l).
The specific activity ofADA in 2l case cancer tissues(0.096±0.051
U/mg protein) was much higher than thosein the normal tissues around
the cancers0.043 ± 0.03 3U/mg protein).the difference
wasstatistically highly significant(t=.86,P<0.01). These data
suggested that ADA activity may be a useful in dex in evaluating
cancer.
出处
《癌症》
SCIE
CAS
CSCD
北大核心
1995年第1期30-32,79,共4页
Chinese Journal of Cancer
基金
江西省自然科学基金
关键词
腺苷脱氨酶
免疫
肿瘤
Adenosine deaminase Cancer Immunity
