摘要
本文用Doppler超声从彩色Doppler血流显象法观察19例肥厚性心肌病患者口服异搏定后,左心室高动力收缩状态获缓解,左室舒张早期充盈功能改善,从而使左心功能得到改善。以VLVOT及DE的改善最为明显,可作为观测及估价药物治疗肥厚性心肌病效果的指标。门服异搏定160～320mg/日治疗肥厚性心肌病可获有益的疗效而不致引起严重的副作用。
The effect of verapamil on 19 patients with hypertrophic cardiomyopathy was examined by Doppler echocardiography and colour Doppler flow imaging. After the oral administration of verapamil in HCM patients, VLV and A/E ratio were decreased, AE. DE. EF slope. SV and Cl were increased significantly. It revealed that verapamil could reduce the left ventricular hypercontractile state, improve the left ventricular diastolic filling and thus enhance the cardiac function. Some favourable effects could be obtained by verapamil, orally administered with 160-320mg/day, without severe side effects.
