摘要
7名健康志愿者口服阿司匹林(ASA)片,通过尿药浓度测定发现:碳酸氢钠和肠溶片可减慢ASA体内平均吸收时间(MAT)(P<0.01)。但碳酸氢钠对ASA体内平均滞留时间(MRT),血浆T_(1/2)和AUC均无影响,也不妨碍其延长出血时间的作用。另外,肠溶片使ASA的MRT延长(P<0.01),并使延长出血时间的作用推迟和减弱。因此,碳酸氢钠与ASA合用不致发生配伍性拮抗作用。
Seven healthy volunteers were given aspirin, aspirin with sodium bicarbonate(SB)and enteric-coated aspirin, respectively .Results showed SB led to increase mean absorption time (MAT)of aspirin (P<0.01). However, aspirin mean residence time (MRT), plasma T1/2, area under the curve (AUC)and effect of prolonged bleeding time (EPBT) did not change.Enteric coated tablets signifi-cantly prolonged aspirin MRT(P<0.01), while the EPBT is decreased and delayed. It is concluded that the possibility of an antagonism between aspirin and SB at usual doses appears to be unlikely.
出处
《新药与临床》
CSCD
北大核心
1989年第4期245-247,共3页
关键词
阿司匹林
碳酸氢钠
药物动力学
aspirin
sodium bicarbonate
enteric-coated tablets
pharmacokinetics
gastrointestinal hemorrhage
