摘要
口服噻氯匹定(ticlopidine)能抑制胶原诱导的血小板血栓烷B_2(TXB_2)生成。大剂量(500mg/d)可使TXB_2生成很快降低,停药1wk后恢复正常。给小剂量(250mg/d)时TXB_2的减少出现较晚,恢复亦快。噻氯匹定对ADP诱导的血小板TXB_2生成也有显著抑制作用。噻氯匹定的抗血小板作用至少有部分与抑制花生四烯酸的代谢有关。
Oral administration of ticlopidine had an inhibitory effect on collagen-induced platelet thromboxane B2(TXB2) production .In high dose group(500 mg/d), TXB2 production was rapidly decreased and returned to normal level 7 days after discontinuing ticlopidine; whereas in low dose group(250 mg/d),the decrease of TX B2 production appeared to be slower and recovered more rapidly when the drug was discontinued.It was also shown thai ticlopidine could significantly inhibit platelet TXB2 formation stimulated by adenosine diphosphate(ADP) .These results suggested that antiplatelet efficacy of ticlopidine was shown,in part,to inhibit arachidonic acid metabolism of platelets.
出处
《新药与临床》
CSCD
北大核心
1989年第2期93-95,共3页
