摘要
诺米芬辛是70年代后期应用于临床的非三环,非四环类新型抗抑郁药。系异喹林衍生物,具有抗抑郁作用。该药对抑郁情感效果佳,有效率78％。日服50-100mg时显效,大部分病人于服药后3-10d产生效果,无抗胆碱能效应,不良反应少。对肝功,心电图几乎无影响。因对心血管损害轻微,使用安全,故对老年患者也是值得选用的抗抑郁剂。
Nomifensine is a new remedy accepted in clinic in later 1970.Chemically it is a derivative of isoquinoline, i.e. neither tricyclic nor tetracyclic compounds. Our results further proved that it is quite effective to terminate the depressive state in '90 patints by dosage 50-100 mg daily, given orally.Clinical release proved to be as a whole 78%.There were no severe adverse reactions including antiacetylcholin-ergic effects, EKG changes or impaired hepatic functions ever noticed. Senility is not an essential factor for medication.
出处
《新药与临床》
CSCD
北大核心
1989年第1期8-11,共4页
关键词
诺米芬辛
抑郁症
焦虑
nomifensine
depression
amitriptyline
anxiety
