摘要
本文对２１例原病理诊断为ＰＲＭＳ的标本，应用特殊染色Ｍａｓｓｏｎ、ＰＡＳ、ＰＴＡＨ及免疫组织化学Ｖｉｍｅｎｔｉｎ、Ｄｅｓｍｉｎ、ＨＨＦ－３５、Ｍｙｏｇｌｏｂｉｎ、Ｍａｃ３８７、α－ＡＴ、Ｓ－１００蛋白、ＮＳＥ、Ｃ－ｋｅｒａｔｉｎ等标记，结合病理组织形态观察，结果维持原病理诊断的９例，修改诊断为ＭＨＦ的８例，ＰＬＭＳ２例，ＰＬＰＳ１例，恶性蝾螈瘤１例。９例ＰＲＭＳ均为男性，年龄２７～７２岁，中位年龄数５２．５岁，于大腿发病最多占７例。提出了确定ＰＲＭＳ的诊断标准和诊断中应注意的下列情况，以防误诊：（１）其它肿瘤中，非肿瘤性横纹肌纤维的显示，（２）坏死的肌细胞释放肌红蛋白，被肿瘤细胞非特异性的吸收，（３）一些恶性肿瘤存在有向骨骼肌的分化。强调了在鉴别诊断中应用免疫组织化学或电镜观察的必要。
Specimens of 21 cases previously dignosed as pleomorphic rhabdomyosarcoma (PRMS) were selected for this study. Histochemical and immunohistochemical methods were used. Results: Of the 21 cases studied, 9 cases were confirmed to be PRMS, 8 cases were rectified as malignant fibrohistocytoma (MFH), 2 cases as pleomorphic leiomyosarcoma (PLMS), 1 case as pleomorphic liposarcoma (PLPS) and the last case as Triton tumor. In the diagnosis of PRMS one should be very careful to avoid the following pitfalls: (1) Entraped non-neoplastic skeletal muscle fibers in other tumors; (2) The tumor cell non -specific absorption of myoglobin released from necrotic muscle cells; (3) Presence of skeletal muscle differentiation in other malignant tumors. PRMS can be distinguished from other pleomorphic sarcomas provided that well fixed tumor tissue is available for immunohistochemical staining and electron microscopy.
出处
《诊断病理学杂志》
CSCD
1995年第2期79-81,共3页
Chinese Journal of Diagnostic Pathology
关键词
多形性
横纹肌肉瘤
超微结构
鉴别诊断
Pleomorphic rhabdomyosarcoma
Immunohistochemistry
Ultrastructure
