摘要
本文内容包括：①皮肤老化引起皱纹的病理生理学基础；②影响皮肤老化引起皱纹的一些因素；③防治皮肤皱纹的一些措施．皮肤老化时，表皮角层水合能力下降，皮肤表面水脂化合物含量也减少，真皮胶原纤维合成减少及弹力纤维变性等，在皱纹的形成与发展上起到重要作用．另外，光线对皮肤的损伤作用十分明显，称为光老化，其病理改变与皮肤的自然老化还有所不同．近年来人们越来越关注抽烟与面部皱纹的关系，发现抽烟者皮肤皱纹的出现比他的实际年龄可提早２０年．作者研究了皮肤老化与体内维生素Ａ含量的关系，结果表明：年龄越高者，血清维生素Ａ含量越低，其皮肤皱纹越明显．防治皮肤皱纹的一些措施，包括身体的健康养护，注意饮食睡眠，消除精神压力，养成不抽烟的良好习惯，避免日光性损伤等．采用药物预防，如维生素Ａ、Ｅ、Ｃ及维甲酸，硒化物等，可起到生物学调节作用．
Abstract The contents of this paper include1)the pathophysiologic basis of skin aging and the wrinkle;2)the contributing factorsin the development of the skin aging;3)the prevention and treatment for skin aging and wrinkle.It is well known that a series of metabolic,functional and morphological changes have been gradually developed during the course of the skin aging.Sun light and smoke are considered to be act as disadvantage factors in skin aging.The damagins effect of sun light on the skin is called light aging of the skin,the dermatological alterations of the light aging of the skin are different from those of the natural agins of the skin.The authors investigated the relationship between the skin aging and the amount of vitamin A in serum.The results show that the higher the age,the lower the amounts of the vitamin A in serum,and the wrinkles are appeared much more.
