摘要
以黄曲霉毒素Ｂｌ（ＡＦＢ１）诱发Ｗｉｓｔａｒ大鼠肝癌的短期动物模型，观察了中药复方丹参提取液（Ｃｐｄ．Ｓ．Ｍ）对ＡＦＢ１启动诱癌的影响。结果表明：Ｃｐｄ．ｓ．Ｍ能明显抑制ＡＦＢ１诱发的变异肝细胞灶和结节数。同时，实验也再次证明了复方丹参提取液具有抗纤维化作用。
The purpose of this present study is
to see whether the liquid compound Salvid Miltiorrhiza Bunge(Cpd
S.M)has an inhibiiory effect on hepatocarcinogenesis induced by
alfatoxin Bl in rats.Animal model was perfomed with Solt-Farber`s
method and quantitative study of modified liver cell foci and nodules
with altered enzyme was carried out by γ-glutamyl
transpeptidass(GGT)stainingon liver sectioms. The results reveaied
that the number and area of GTpositive foci and nodules were
signifi-cantly less and smaller in Cpd.S.M treated animais than those
in untreated controls.Moreover oiver fibro-sis was also markedly
attenuated in these treated rats.
出处
《肝脏病杂志》
CSCD
1995年第4期199-201,共3页
关键词
复方丹参提取液
肝肿瘤
癌前病变
预防
alVia Miltiorrhiza Bunge
Alfatoxin B1 Hepatocarcinogenesis
