摘要
在无国产抗－ＨＣＶ试剂供应的１９９０和１９９１年，甲地观察输血者９０名（不筛查ＡＬＴ），乙地筛查ＡＬＴ观察输血者６４名。输血后ＨＣＶ感染率甲地４５．６％，乙地１８．８％，ｐ＜０．０１；其中输血后丙型肝炎发生率甲地４１．１％，乙地１４．１％Ｐ＜０．０１，甲地观察二年未发现抗－ＨＣＶ阴转；输血距抗－ＨＣＶ阳转甲地３８．４±１１．８天，乙地４２．９±１５．９天；输血后ＡＬＴ异常率甲地４４．４％，乙地２１．９％，输血距ＡＬＴ异常甲地４８．２±１６．８天（观察二年ＡＬＴ异常率２７．８％），乙地５１．９±２０．９天。输抗－ＨＣＶ阳性、阴性血受血者，其ＨＣＶ感染率８８．２％（４５／５１）和７．８％（８／１０３）。既往ＨＣＶ隐性感染的受血者，输后丙型肝炎发病率５２．９％（１１／２２），同时发现３例输血后抗－ＨＣＶＳ／ＣＯ值渐低，２例阴转，似有ＨＣＶ中和性抗体存在。
prospective study on relation
between infection of hepatitis C virus(HCV)and post-transfusion was
performed in two county hospitals,one named as A where the blood
donors was only tested blood type and the another named as B where
the blood donors was screening ALT and HBsAg beforc dona-tion
without detecting anti-HCV.90 blood recipients in hospital A and 64
in B were followed up for two years and 6 months respectively, The
HCV infection rates were 45.6%for reciepients in hospital A and
18.8%in hospital B( P<0.01).The incidence rates of post-transfusion
hepatitis C (PT-HC) were 41.1% for hospital A and 14. 1%for B(
P<0.01).The first time of anti-HCV positive conversion were 38.4±11.
8 days for A and 42.4±15.9 days for B after blood transfusion.
The first time of abnormal ALT were 48.2 ±16.8 days for A and 51.9±
20.9 days for B after blood transfusion.The infection rates were
88.2%(45/51) for blood with anti-HCV avd 7.8%(8/103) for blood
without anti-HCV in total.The inci-dence rate of recipients who were
positive of anti-HCV before transfusion was 52.9%(11/21).3 cases
showed titerof anti-HCV decreasing,anti-HCV negative conversion
occurred in 2 cases during followed up,the results indicated that
these reciepients might contain neutralizaed antibody to-HCV.
出处
《肝脏病杂志》
CSCD
1995年第3期165-167,共3页
