摘要
本实验选用四氯化碳诱导大白鼠所致的肝硬化门静高压模型，以哌唑嗪作为阳性对照，通过１４周给药，以直接测定门脉压作为观察的主要指标，了解中药８９１０方对大鼠门脉高压形成的影响。结果显示：中药８９１０组门脉压显著低于单纯肝硬化模型组（生理盐水组），而与哌唑嗪相当，免疫组织化学结果显示：中药８９１０方抗Ⅰ、Ⅲ型胶原和板层素沉积作用显著优于哌唑嗪，提示其抗门脉高压形成作用与之有不尽相同的作用机理。
his study investigated the effect of
Chinese herbs 8910 on development of portal hypertension of
CC14-induced rat liver cirrhosis.Four groups, the model of liver
cirrhosis,the 8910,prazosin and normal control groups were set up in
our experiment. The rats were sacrificed after 13 weeks and the the
portal pressure were directly measuled, and collagen type Ⅰ and type
Ⅲ and laminin in liver tissue were meas-ured The results showed that
Chinese herbs 8910 had the same effect as prazosin on significantly
reduc-ing rat portal hypertension and had more significant effect on
anti-accumulation of collagen type Ⅰ,Ⅲ and laminin in liver.
出处
《肝脏病杂志》
CSCD
1995年第3期161-162,共2页
关键词
门静脉高压
中药
8910方
Chinese Herbs Portal hypertension Liver cirrhosis Rat Laminin
