摘要
根据自身免疫性甲状腺疾病发病机制新的独特型—抗独特型免疫网络学说，用兔抗人ＴＳＨＡｂ检测ＴＳＨ抗独特型抗体（ＴＳＨＡｂ２）。以正常人为对照，以其结合率ｘ＋２ｓ为正常值上限，大于此值为阳性。６０例ＴＲＡｂ阳性病人中，６５％病人ＴＳＨＡｂ２阳性，而４０例ＴＲＡｂ阴性病人中，只有５％病人ＴＳＨＡｂ２阳性。两组差异显著（Ｐ＜０．０５）。ＴＲＡｂ阳性组中，ＴＲＡｂ和ＴＳＨＡｂ２呈正相关（ｒ＝０．６４５，Ｐ＜０．０１）。同时用制备的ＴＳＨ抗体吸附ＴＲＡｂ阳性血清后再检测ＴＲＡｂ，吸附前后差异显著（Ｐ＜０．０５）．抗ＴＲＡｂ抗体的检出为我们探讨Ｇｒａｖｅｓ病发病机制提供了一条新思路。
Based on the idiotypic-antiidiotypic immune network theory of pathogenesis of autoim mune thyiroid disease,TSH anti-idiotypic antibody (TSHAb2) was detected with rabbit anti hTSH antibody (TSHAb1) in patients with Graves'disease. In sixty thyrotrpin receptor antibody positive cases (TRAb+) ,sixty five percent had positivity for TSHAb2, while only five percent were positive for TSHAb2 in forty TRAb(-) patients. The difference was significant (P<0.05) and TRAb was positively correlated with TSHAb2 in TRAb (+) group (r=0. 645,P<0.01). Moreover,a significant difference was seen in the number of TRAb (+) patients before and after absorption of TRAb (+) sera with TSH antibody (P<0.05). The finding of anti-TSHAb antibody points out an alternative approach to the pathogenesis of Graves' disease.
出处
《标记免疫分析与临床》
CAS
1995年第3期129-131,共3页
Labeled Immunoassays and Clinical Medicine
关键词
GRAVES病
TRAB
抗体
TSH受体
Goiter
exophthalmic
Antibody
TSH receptor Antibody
antiidiotypic
