摘要
通过对２０３例盆腔子宫内膜异位症和４０６例随机人群对照的流行病学调查，发现子宫内膜异位症的发生可能与是否受过高等教育、体重、个人疾病史、Ａ血型及妇科疾病家族史等因素有关。提示，月经血倒流是子宫内膜异位症形成的基础，是否发病还取决于机体神经、内分泌和免疫系统的健全，以及由遗传等因素决定的人体易感性。
03 patients
with pelvic endometriosis, all Beijingresident were collected from the Peking Union
MedicalCollege Hospital and the Beijing Obstetrical and Gyneco-logical Hosprtal. The diagnosis
of endometriosis wasconfirmed by pathological examination of surgical speci-mens in 186
patients and by aspiration of chocolate sub-stance under laparoscopy in 17. Two population
con-trols, age matched± 1 year . were randomly selected foreach patient from the same
residential area , after carefulpelvic exarninations and ultrasonographies. A question-aire for
any possible risk factors to endornetriosis was de-veloped and with this questionaire a face to
face inter-view for each subject was carried out by the trained in-terviewers. All interviews were
tape recorded and calcu-lated in a AST 386 computer. The continuous logisticregression for
matched stes was used to obtain a maxi-mum likelihood point and to control the potential
con-founding effects of selected variables. Relative risk(RR) substituted for odds ratio together
with the 95%confidence intervals was estimated. All the resuhs wereadjusted for the variables
of the model including somerelevant factors of menstruation, pregnancy and contra-ception. An
increased risk for endometriosis was foundto be related to women who had a higher level of
educa-tion. Even it was adjusted for age of first marriage andpregnancy , gravidity, parity ,
contraception and all oth-er variables of the model, the relative risk was 1. 84 forendometriosis.
Therefore, it is the education level itselfthat plays a true role in development of
endometriosis.Although there was a trend in risk for endometriosis inheight, it was statistically
insignificant. Weight howev-er, is a better predictor than height of risk for en-dometriosis. There
was a significantly greater risk of en-dometriosis for women who underweight. The distribu-tion
of ABO blood groups in the patients was differentfrom that in the controls. The occurance of
blood groupA was more frequently in the patients than in the con-trols. There was an apparent
relationship between therisk of endometriosis and the past illness, such as aller-gic episodes,
autoimmunal diseases. tonsillectomy or ap-pendectomy and hyperplasia of mammary glands.
Apositive family history of endometriosis or benign tumorsof pelvis was also found to be related
to the occurence ofendometriosis.
出处
《中华医学杂志》
CAS
CSCD
北大核心
1995年第1期34-36,共3页
National Medical Journal of China
基金
国家自然科学基金
