摘要
应用小剂量肝素治疗１４例慢性特发性血小板减少性紫癜症患者。１４例患者均为难治性者，其中男５例，女９例，年龄１９～７６岁（平均４７岁）。病程６个月～２０年（平均６．３年）。所有患者在肝素应用前均经泼尼松及多种免疫抑制剂正规治疗无效，泼尼松应用剂量在肝素治疗期间均减至１０ｍｇ／ｄ。肝素应用方法为腹部脐周皮下注射１２５０Ｕ／次，２次／ｄ。肝素治疗后，显效１例（７％）；良效６例（４３％）；进步３例（２１％）；无效４例（２９％）。总有效率为７１％。１０例有效病例血小板上升达高峰所需时间为１０～２３天（平均１８天）。肝素治疗前后，凝血功能、肝和肾功能、尿常规、心电图检查等均无变化。
ourteen cases(5 male and 9 female ,mean age 47years) of chronic idiopathic thrombocytopenic purpura(CITP) were treated with low dose of heparin. The ill-ness courses of patients were 6 months to 20 years( mean 6. 3 years),and all of them were resistant to theconventional corticotherapy and other immunosup-pressive drugs.Heparin was given subcutaneously in adose of 1250 U twice a day. After treatment , one case( 7%) got CR, 6 ( 43%) PR,3( 21%) improvement,and 4 failure,The total response rate was 71%.In 10responders,it takes 10 to 23 days of therapy(mean 18days) for platelets to reach the peak values. No abnor-mal findings were observed in coagulation system,liverand kidney test,EKG examination during heparin treat-ment.
出处
《中华血液学杂志》
CAS
CSCD
北大核心
1995年第4期196-197,共2页
Chinese Journal of Hematology
基金
法国巴黎IVS资助
