摘要
为了进一步探讨体外循环心脏手术对机体免疫功能的影响，以及环氧化酶抑制剂的免疫增强作用，我们将４０例心脏手术病人分为４组。分别检测术前、术后２天、７天的白细胞介素－２（ＩＬ－２）、ＩｇＭ、ＩｇＧ、ＩｇＡ、Ｃ_３的变化。结果表明，体外循环心脏手术可引起ＩＬ－２、ＩｇＧ、Ｃ_３下降，ＩＬ－２下降的程度与体外循环转流的时间有关。环氧化酶抑制剂可使术后ＩＬ－２的水平有部分恢复。结论为体外循环心脏手术后ＩＬ－２及免疫球蛋白下降并持续一周，补体水平亦降低，这不仅使机体抵抗力下降，易并发感染；同时激活补体后可导致重要器官的损害，故在围术期监护中应予以重视。
For the purpose of studying the influence of open heart surgery with CPB on the immune system,the changes of interleukin-2,immunoglobulins and complements were determined in 40 patients.They were divided into 4 groups.IL-2,IgG,IgM,IgA and C_3were tested before operation and 2 days,7days postoperatively. The results showed:open heart surgery with CPB depressed the production of IL-2,IgG and C_3.Cyclo-oxydase inhibitor partly reduced the depression of IL-2.
出处
《中华胸心血管外科杂志》
CSCD
北大核心
1995年第6期326-328,共3页
Chinese Journal of Thoracic and Cardiovascular Surgery
关键词
体外循环
白细胞介素
心脏外科手术
Cardiopulmonary bypass
Interleukin- 2
Cyclo-oxydase inhibitor
Complement
Antibody
