摘要
作者观察了２０例烧伤患者（ＴＢＳＡ≥３０％）血清粒细胞集落刺激因子（Ｇ－ＣＳＦ）的变化，探讨了其与感染的关系。８例ＴＢＳＡ≥５０％的患者，７例（８７．５％）出现早期（伤后１～５天）Ｇ－ＣＳＦ升高；５例ＴＢＳＡ≥７０％的患者，除１例有创面脓毒症而Ｇ－ＣＳＦ无变化外，其余患者均在伤后第１天即升高；１２例ＴＢＳＡ＜５０％的患者，７例（５８．３％）升高但为时较晚（伤后５～９大）。对１１例临床诊断为创面脓毒症患者的分析表明，Ｇ－ＣＳＦ的改变与感染有关，创面脓毒症时９０％的患者血Ｇ－ＣＳＦ水平升高。因此，大面积烧伤患者，尤其ＴＢＳＡ≥５０％者，出现Ｇ－ＣＳＦ升高应考虑全身感染的存在。对烧伤面积很大但Ｇ－ＣＳＦ不高者应警惕免疫功能低下的存在。
AbstractSerum G-CSF level was assaved in 20 burned pa-tients(TBSA≥30%)2 weeks postburn. In 11 of themplasma endotoxin was also measured.The resultsshowed serum G-CSF level was increased in 87.5%(7/8)of burned patients with exceeding 50%TBSA andin 58.3%(7/12) of patients with 30%～50%TBSA,and in the former it was earlier increased(1～5 daypostburn ) than the latter(5～11 day postburn). Serum G-CSF was increased in 90%of the burned pa-tients with wound sepsis. Increase of serum G-CSF inburned patients,especially in those exceeding 50%TBSA, indicates the occurrence of sepsis.
出处
《中华外科杂志》
CAS
CSCD
北大核心
1995年第7期403-405,共3页
Chinese Journal of Surgery
