摘要
以３５ｇ重量压迫裸露的大鼠胸Ｔ＿（７～８）脊髓背侧５分钟，造成脊髓的压迫性损伤。伤后立即向蛛网膜下注射抗强啡肽Ａ＿（１～１３）血清１０μｌ（滴度为１：３００００）或阿片ｋ受体桔抗剂ｎｏｒ－ＢＮＩ（１００ｎｇ），并在创伤１、２、３小时分别给上述剂量的半量，观察伤后恢复情况。结果表明，给予抗强啡肽Ａ＿（１～１３）血清后大鼠双后肢肌张力和运动功能的恢复明显快于ｎｏｒ－ＢＮＩ组或对照组；ｎｏｒ－ＢＮＩ组双下肢运动功能恢复快于对照组。组织学观察表明，强啡肽抗血清和ｎｏｒ－ＢＮＩ均可有效阻止或减轻脊髓受压损伤后产生的局部组织坏死，出血及神经细胞变性等病理改变，强啡肽抗血清作用更显著。
AbstractApronounced and reversible spinal cord compres-sion injury was performed by the compression of a met-al plate 2.2mm × 5. 0mm in size to the exposed spinaldura and loaded with 35g weight for 5 minutes at T_(7～8)Anti dynorphin serum at 10μl(1 :30000)or K an-tagonist nor-BNI at 100 ng was administered intrasub-arachnoidly shortly after the injury, with half dose ap-plied 1,2,3 h after the injury for another three times.The recovery of neurological function was investigated.The results showed that the recovery of the muscletension and motor function of the hindlimb in antidynorphin serum group is markedly faster than that inboth control and nor-BNI groups. Also the recovery ofmotor function in nor-BNI group is favourable at theearlier stage of injury, comparing to the control group.There were no significant differences in the change ofmean arterial pressure and blood physiological parameters among the three groups.
出处
《中华外科杂志》
CSCD
北大核心
1995年第6期378-381,共4页
Chinese Journal of Surgery
基金
国家自然科学基金
