摘要
为验证第二代质子泵抑制剂兰索拉吐治疗十二指肠溃疡的疗效，对经胃镜检查诊断的治疗活动期十二指肠溃疡患者３８例作了观察，并与奥美拉唑组３４例进行了对照。结果两组十二指肠溃疡４周的愈合率分别为９７．４％和９１．２％，有效率分别为１００％与９７．１％（Ｐ＞０．０５）；疼痛消失率两组分别为１００％和９３．５％（Ｐ＞０．０５），而３天内疼痛消失率分别为７４．３％和５１．６％（Ｐ＜０．０５）。兰索拉唑治疗过程中未发现有副作用。提示兰索拉唑是治疗十二指肠溃疡有效的和安全的药物。
o evaluate the efficacy of a second generation acid pump inhibitor-lansoprazol(L) a controlled clinical trial in 72 patients of duodenal ulcer was carried out with omeprazol (O)as control.The results showed that the ulcer healing rate after 4-week treatment was 97.4%in lansoprazol group and 91.2%in omepra-zol, while the effective rate was 100%and 97.1%respectively(P>0. 05).Ulcer related pain was relieved more quickly in lansoprazol group. The pain relief rate after treatment of 3 days was different significantly between the two group,being 74.3%(L)and 51.6%(O) respectively (P<0. 05).No marked side-effect was observed in lansoprazol group. It is shown that lansoprazol is effective and safe for treatment of duede-nal ulcer.
出处
《中华内科杂志》
CAS
CSCD
北大核心
1995年第9期606-608,共3页
Chinese Journal of Internal Medicine
