摘要
对３７例急性心肌梗塞（ＡＭＩ）患者入院即刻、溶栓治疗（或非溶栓组一般治疗）后１、６、２４小时，第２、３、５、１５天测周围静脉血中血小板颗粒膜蛋白（ＧＭＰ－１４０）的数量，进行动态观察，并分析其与梗塞相关冠状动脉（ＩＲＡ）再通的关系。结果表明：溶栓治疗后血个板ＧＭＰ－１４０存在着升高和降低两种结果：ＩＲＡ再通组ＧＭＰ－１４０在溶栓后１～６小时显著下降；ＩＲＡ未通组ＧＭＰ－１４０在溶栓后１～６小时较溶栓前显著上升。提示血小板活性的改变与ＡＭＩ血栓形成和血栓溶解关系密切，血小板ＧＭＰ－１４０在溶栓后的迅速下降可作为临床判断ＩＲＡ再通的新指标。
Platelet granule membrane glycoprotein(GMP-1 40)level was measured by using ￣(125)I labelled mono-clonal antibOdy in 37 patients with acute myocardial infarction before and after thrombolytic therapy。In anonthrombolysis group, it was shown that platelet GMP-140 increased significantly at the moment of ad-mission and reached peak value 4 8 hours after AMI attack,then it decreased gradually and returned tobaseline on the fifth day, In the thrombolysis group, with the patency of infarct related arteries,it droppedquickly(1～6 hours)after thrombolytic therapy; if the infarct related arteries were not patent,platelet(GMP-140 increased rapidly after thrombolytic therapy and reached the highest at 6 hours, then it returnedto baseline on the third day, It is suggested that the changes of platelet function could play an importantrcle in thrombus formation and lysis; the rapid decrease of the number of GMP-140 molecules on plateletsurface might be a new index for the pateacy of infarct related arteries.
出处
《中华内科杂志》
CAS
CSCD
北大核心
1995年第5期302-304,共3页
Chinese Journal of Internal Medicine
