摘要
对未治Ⅱ型糖尿病患者１８例，未治原发性高血压病患者３７例，和正常对照２８例进行口服葡萄糖耐量试验（ＯＧＴＴ），检测血糖和胰岛素水平，同时还测定红细胞膜钠钾泵、钙泵活性。结果显示，糖耐量正常或异常的高血压病患者与对照组相比，存在明显高胰岛素血症，钠钾泵、钙泵活性降低，而Ⅱ型糖尿病伴高血压病患者和不伴高血压病者间比无明显差别。提示高血压病者存在胰岛素抵抗及（或）高胰岛素血症，而糖尿病伴发高血压病与胰岛素有关。胰岛素抵抗不仅影响细胞膜钠钾泵、钙泵的活性还影响其他血压调节的因素。
To study the pathogenesis of hypertension associated with NIDDM, 18 patients with NIDDM,22 patients with essential hyper-tension, 15 patients with both hypertension and NIDDM and 28 control subjects were enrolled.None of them had taken medicationfor high blood pressure or hyperglycemia prior to examination.Plasma glucose,insulin levels at fasting and following an oral glu-cose load (75 g)were measured. The Na￣+ -K￣+ -pump and ca￣(++) -pump activities in the membranes of their erythrocytes were also as-sessed. Overall,as compared with the control , hypertensive patients with nprmal or impaired glucose tolerance had hyperinsulinemia,and decreased activities of Na￣+ -K￣+ -pump and Ca￣(++) -pump,while between NIDDM patients with hypertension and those without hy-pertension there was no significant difference. These results demonstrate that hyperiensive patients have insulin resistance and orhyperinsulinemia,and there is a link between NIDDM with hypertension and insulin. The insulin resistance changes activities of theNa￣+ -K￣+ -pump and Ca￣(++) -pump in the cell membrances and influences other factors that modulate blood pressure.
出处
《中华内分泌代谢杂志》
CSCD
北大核心
1995年第4期214-216,共3页
Chinese Journal of Endocrinology and Metabolism
关键词
糖尿病
高血压
胰岛素抵抗
钠钾泵
钙泵
NIDDM Hypertension Insulin resistance Hyperinsulinemia Na￣+ -K￣+ -pump Ca￣(++) -pump
