摘要
报道２６例老年人急性白血病的治疗。联合化疗组１０例，完全缓解（ＣＲ）者３例，部分缓解（ＰＲ）２例，总有效率５０．０％；小剂量阿糖胞苷（ＬＤＡｒａ－Ｃ）治疗组１２例，ＣＲ３例，ＰＲ１例，总有效率３３．３％。两组比较，差异有显著性（Ｐ＜０．０１），两组于骨髓抑制期死亡者分别为１例和２例，而姑息治疗４例无一例达ＣＲ或ＰＲ，提示ＬＤＡｒａ－Ｃ治疗细胞毒作用并不低，联合化疗可提高治疗水平。因此应在强有力支持治疗的情况下尽量给予标准联合化疗，对有重要脏器损伤或感染者可给减量或ＬＤＡｒａ－Ｃ治疗。
Abstract The effect of treatment of acute leukemia in 26 elderly patients were reported. In standard or intensive combination chemotherapy group, 3 out of 10 patients achieved complete remission (CR) and 2 achieved partial remission (PR). In low-dose Ara-C group, 3 of 12 patients achieved CR and one achieved PR.Cytotoxicity related mortality in the two group was 10.0%(1/10) and 16.7%(2/12) respectively. 4 cases received palliative treatment, none of them achieved CR or PR. The results from this study showed that reduction of eraly death rates and increase of remission rates can be achieved by using standard or intensive combination chemotherapy and vigorous supportive care should be given at the same time.
出处
《中华老年医学杂志》
CAS
CSCD
北大核心
1995年第3期137-139,共3页
Chinese Journal of Geriatrics
