摘要
目的:探讨付氧酶(PON)基因多态性与单纯2型糖尿病及2型糖尿病肾病(DN)的关系方法:应用PCRRELP法检测97名正常人(对照组)、154例单纯2型糖尿病、145例2型DN患者PON1PON2、PON3多态性。结果:PON2(G148A)各基因型频率3组间比较差异有显著性(P<0.001)PON2(C311S)各基因型频率3组间比较差异有显著性(P<0.001)。PON1(Q192R)、PON1(L55M)、PON(A99A)各基因型频率3组间比较差异无显著性(P>0.05)。结论:PON2(G148A)和PON2(C311S)基因多态性都可能作为DN的预测指标,PON1(Q192R)、PON1(L55M)、PON3(A99A)可能与DN发生无相关性。
Objective To explore the relation between the paraoxonase (PON) gene polymorphism and non-insulin- dependent diabetes mallitus(NIDDM )with or without diabetic nephropathies(DN). Methods PCR-RELP was used to detect the PON genotypes in 97 healthy controls, 154 NIDDM patients without DN and 145 NIDDM patients with DN. Results The distribution rates of PON2(G148A)and PON2(C311S)had remarkable differenaces (P<0.001) between DM and DN and control groups. The distribution rates of PON1(Q192R),PON1(L55M)and PON3(A99A)had not remarkable differenaces(P>0.05)between DM and DN and control groups.Conclusion The polymorphism of PON2(G148A)and PON2(C311S) may be prognostic factors in patients with DN; there are no relationships between PON1(Q192R),PON1(L55M), PON3(A99A) and DN.
出处
《吉林大学学报（医学版）》
CAS
CSCD
北大核心
2005年第4期598-601,共4页
Journal of Jilin University：Medicine Edition
基金
吉林省科技厅科技发展计划项目资助课题(2003042802)
