摘要
目的:了解低氧性肺动脉高压的形成机制。资料来源:应用计算机检索Medline1991-01/2004-08的相关文章,检索词“hypoxicpulmonaryhypertension,etiology”,并限定文章语言种类为English。同时计算机检索《中国临床康复》杂志2003-01/2004-08的相关文章,限定文章语言种类为中文,检索词“肺动脉高压”。并且手工检索《中文科技资料目录-医药卫生》1998-01/2004-08的相关文章,检索途径:分类途径。资料选择:对检索到的相关文章中的相关信息进行综述,纳入标准:①随机对照的基础及临床试验。②无论是否为单盲,双盲或非盲法。排除标准:重复性研究及综述性文章。资料提炼:共检索到相关文章22篇,对检索到的12篇文章信息进行综述,10篇综述性及重复性研究的文章予以排除。资料综合:实验研究提示内皮素、一氧化氮、5-羟色胺、肺动脉平滑肌细胞膜钾通道、磷酯酶A2、蛋白激酶C、低氧诱导因子1都参与了低氧性肺动脉高压的形成。结论:低氧性肺动脉高压的形成机制相当复杂,多种分子及细胞膜钾通道参与其中,这些分子及机制的发现为低氧性肺动脉高压的干预和早期康复措施介入提供了新的靶点。
OBJECTIVE:To investigate the forming mechanism of hypoxic pulmonary hypertension. DATA SOURCES: An online search of Medline database was undertaken by using the of 'hypoxic pulmonary hypertension, etiology'to identify the relevant articles published in English from January 1991 to August 2004. Meanwhile, relevant articles published in Chinese Journal of Clinical Rehabilitation during January 2003 and August 2004, the key words were 'hypoxic pulmonary hypertension'with language limited to Chinese. Besides, manual search of relevant articles published from January 1998 to August 2004 was applied to the 'Chinese Catalogue of Technological Data' with the pathway of classification. STUDY SELECTION: The relevant information in the selected articles was reviewed. Inclusion criteria: ① randomized control basic or clinical trials; ② single-blind, double-blind or non-blind method. Exclusion criteria: repetitive study and reviews. DATA EXTRACTION: Twenty-six related articles were collected, information in 16 articles were reviewed, and 10 repetitive studies and reviews were excluded. DATA SYNTHESIS: The studies revealed that endothelin, nitric oxide (NO), 5-hydroxytryptamine (5-HT), pulmonary artery smooth muscle cells membrane potassium channels, phospholipase A2, protein kinase C and hypoxia-inducible factor-1 were involved in the formation of hypoxic pulmonary hypertension. CONCLUSION: The forming mechanism of hypoxic pulmonary hypertension is very complex. Some cell molecules and potassium channels are involved in the process. The identification of the molecules and mechanism has provided new targets for the intervention and early rehabilitation of hypoxic pulmonary hypertension.
出处
《中国临床康复》
CSCD
北大核心
2005年第23期162-163,共2页
Chinese Journal of Clinical Rehabilitation
