摘要
目的研究干扰素α/β(IFN-α/β)受体蛋白在慢性丙型肝炎(CH-C)、丙型肝炎肝硬化(LC)患者肝组织中的表达。方法对CH-C和丙型肝炎LC患者采用免疫荧光技术检测IFN-α/β受体蛋白是否存在和在肝组织中的存在程度。并依据IFN治疗效果,将CH-C组分为有效组和无效组,研究了不同治疗效果与肝脏中IFN-α/β受体蛋白表达之间的关系。结果肝细胞中,IFN-α/β受体蛋白在门静脉周围比中心静脉周围要多,在肝小叶中分布不均;CH-C组与丙型肝炎LC组IFN-α/β受体蛋白在肝脏组织中的表达阳性率间差异有显著性意义;IFN治疗有效组与无效组IFN-α/β受体蛋白在肝组织中的表达阳性率间差异有显著性意义。结论慢性丙型肝病患者肝组织中IFN-α/β受体蛋白的表达与IFN疗效相关,测定肝脏中IFN-α/β受体的表达水平对预测IFN疗效是有意义的。
Objective To study the expression of interferon Receptor(IFN Rc) protein in liver tissue of patients with CH-C and LC.Methods In this study,the objects were patients with chronic hepatitis C or HCV related liver cirrhosis who seroposistive for HCV RNA underwent liver biopsy for diagnostic purposes.We detected the existence of IFN-Rc proteins and the degree of their existence in liver tissue of the patients by immunofluorescence.According to the response to IFN therapy,patients of CH and LC were divided into IFN treatment responsive and non-responsive groups,respectively.We studied the correlation between these results and expression of IFN-α/βRc protein in liver tissue.Results In liver tissue,the expression of IFN-α/βRc protein in the surrounding of portal vein was more obvious than that in the central vein,and expression of IFN-α/βRC protein in the hepatic lobule was poorly distributed.Compared the CH group with LC group,as well as IFN treatment responsive group with the non-responsive group,the expression of IFN-α/βRc protein in liver was more obvious and this had significant difference in statistics.Conclusion Expression of IFN-α/βRc protein in the liver of the patients with chronic HCV related liver disease is likely to be involved in the response to IFN therapy and it may be useful to predict the effect of the IFN treatment by testing the expression of IFN-α/βRc protein.
出处
《中国全科医学》
CAS
CSCD
2005年第13期1065-1067,共3页
Chinese General Practice
