摘要
用ｐ５３的单克隆抗体ｐＡｂ１８０１对７３例原发乳腺癌进行免疫组化研究，并观察ｐ５３阳性表达率与肿瘤大小，组织学分极，临床分期，雌激素受体（ＥＲ）以及腋窝淋巴结转移的关系。结果表明：７３例中１７例癌细胞核Ｐ５３呈阳性表达，占２３％。ｐ５３阳性表达与肿瘤组织学分级、临床分期、ＥＲ等因素明显相关。在组织学分级Ｓ级，临床分期Ⅳ期以及ＥＲ阴性病例中，ｐ５３阳性率最高，差异显著（Ｐ＜０．０１）。而与肿瘤大小及腋窝淋巴结转移无密切关系（Ｐ＞０．０５）。对３４例病人的术后回顾性随访也表明：Ｐ５３阳性病人存活期明显低于阴性病人（Ｐ＜０．０１）。
the association of nuclear immunoreaction of P53 protein with clinical and histological parameters of breast cancer patients were analysed.Tissuesfrom 73 primary breast cancer specimens were processed by formaline fixation,paraffin embedding and stained with anti-P53 monoclonal antibody (pah 1801). p53immunoreactivity was detected in the nuclei ofcancer cells in 17 cases(23%).Thenuclear p53 immunoreaction was closely associated with high histologic grade(P<0.01),advanced clincal stage(P<0.05)and negative estrogen receptor status(P<0.01).Of 34 cases which had been followed up for more than 50 months it was found that positive nuclear p53 immunoreaction was in remarkable association with short overall survival of patients(P<0.01).
出处
《中国肿瘤临床》
CAS
CSCD
北大核心
1995年第7期480-482,共3页
Chinese Journal of Clinical Oncology
