摘要
目的:通过检测基质金属蛋白酶-1(MMP-1)在慢性牙周炎牙龈组织中的表达和分布特征,探讨MMP-1在慢性牙周炎发病中的作用和临床意义.方法:收集8例因非牙周疾病而需拔牙患者健康牙龈及24例慢性牙周炎患者牙龈组织,按健康对照、牙周袋深度≤4 mm、4～6 mm、＞6 mm分A、B、C、D四组,利用免疫组化方法检测其中MMP-1的表达.结果:正常牙龈组织上皮及固有层MMP-1弱表达,慢性牙周炎患者牙龈组织MMP-1表达明显增高,两者间有显著性差异(P＜0.05).并且MMP-1表达与牙周袋深度间显著正相关(r=0.623,P＜0.01).结论:MMP-1参与慢性牙周炎病变牙周组织的破坏过程,并且其表达随牙周袋深度加深有增加趋势.
AIM:To determine the distribution of matrix metalloproteinase(MMP)-1 in the gingiva of chronic periodontitis and investigate the role of it in the pathogenesis of chronic periodontitis.METHODS:The expression of MMP-1 was observed immunohistochemically in 24 specimens of inflammatory periodontal tissue from chronic periodontitis and 8 specimens of healthy periodontal tissue as control.According to the healthy control group and pocket depth(PD≤4 mm、4～6 mm and >6 mm),the specimens were devided into group A、B、C and D.RESULTS:Low immunoreactivity was detected in the control group,while high expression of MMP-1 was found in the diseased epithelial layer and lamina propria(P<0.05).The deeper PD was the higher the expression of MMP-1 (r=0.623,P<0.01).CONCLUSIONS:MMP-1 from resident gingival cell sources participates in the chronic and destructive course of periodontal inflammation,and its expression increased with PD deepened.
出处
《牙体牙髓牙周病学杂志》
CAS
2005年第7期365-368,共4页
Chinese Journal of Conservative Dentistry
关键词
慢性牙周炎
基质金属蛋白酶
免疫组织化学
chronic periodontitis
matrix metalloproteinase
immunohistochemistry
