摘要
对血吸虫病肝纤维化（ＳＦ）８２例、血吸虫病非肝纤维化（ＳＮＦ）３５例和健康人（ＨＰ）３２例甲襞微循环及肝脏Ｂ超、胶原代谢进行同步观察分析，结果表明；①血吸虫病患者普遍存在甲襞管袢内径缩小、管壁增厚、微血管压力加大、微血流速度减慢等微循环障碍。②ＳＦ患者甲襞微循环障碍不但较ＳＮＦ虑者严重，而且随着ＳＦⅠ期、ＳＦⅡ期、ＳＦⅢ期病情加重．其甲襞微循环各项指标异常的程度也递增。③ＳＦ患者申襞微循环加权积分值与门脉主干内径、门脉管壁厚度等超声指标及ＨＡ、ＨＹＰ等胶原代谢指标治疗前后呈同步变化，有相关关系；而且与门脉主干内径和ＨＡ、ＨＹＰ等指标阳性率相同。提示甲襞微循环观测在一定程度上反映了血吸虫病肝纤维化的病理生理变化。
We tested the patients with schistosomiasis hepato fibrosis (SF,82 cases),schistosomiasis nont-hepato fibrosie (SNF, 35 cases) and nealth people (HP,32 cases) by using the nailfold microcirculation,hepato ultrasound B and collagen metabolize. Results:① The patiens with schistomiasis had generally distubance of microcirculation, consisting of vascular diameter reduced,thickness of capillary wall increased,pressure of microvesse increased and blood flow velocity of microvessel retarded (completely P<0. 01). ②The distubance of microcirculation of SF showed s marked increase over SNF (P<0. 01 or P<0. 05). Its level was increased along with the pathological changes of SFⅠ,SFtⅡ,SFⅢ stages (P<0. 01 or P<0. 05). ②The changes of distubance of microcirculation of SF not only happened at the same time with ones of its portalcaval diameter,thickness of portalcaval truncus wall,Hyaluronate (HA) and Hydroxyprolin (HYP),but closely correlated with the portalcaval diameter,HA and HYP. It is suggested that testing nailfold microcirculation can reflect the changes of pathophysiology of hepato fibrosis with schistosomiasis Japonica.
