摘要
目的观察先心病婴幼儿肌注罗库溴铵的肌松效果、插管条件和安全性.方法 30例先心病择期全麻手术患儿,随机分为3组,每组10例,组Ⅰ、Ⅱ分别肌注罗库溴铵1、2 mg·
ObjectiveTo observe the muscle relaxation,intubation conditions and safety of intramuscular rocuronium in infants with congenital heart disease.MethodsThirty infants scheduled for elective surgical procedures were randomly allocated to injected intramuscular rocuronium (1 or 2 mg/kg) or succinylcholine (4 mg/kg) into deltoid muscle,respectively. The adductor pollicis twitch were measured by accelerometry. Intubation condition were (assessed) at twitch depression to >75%.ResultsThe number of patients achieved >75% twitch depression after (6 min) of drugs administration were 4,9,and 0 (P<0.01). Intubation conditions were consistently good-excellent when twitch depression achieved >75% in all groups. Times of 25% twitch recovery were significantly different after drugs administration (P<0.01).(Conclusion)Intramuscular rocuronium,2 mg/kg,can provide good-excellent (intubation) condition within 4 to 6 min and long duration of action about 2 h. Duration of action of large dose rocuronium might limit clinical utility. Intramuscular succinylcholine does not provide satisfactory tracheal intubating condition in infants with congenital heart disease.
出处
《上海第二医科大学学报》
CSCD
北大核心
2005年第7期744-746,共3页
Acta Universitatis Medicinalis Secondae Shanghai
关键词
罗库溴铵
肌松作用
插管条件
肌注
麻醉
婴幼儿
<Keyword>rocuronium
neuromuscular blockade
intubation conditions
intramuscular injection
anesthesia
infant
