摘要
目的:调查近14年来武汉地区溃疡性结肠炎(UC)的患病情况与临床病理特点,为进一步研究UC的发病情况与危险因素提供依据。方法:回顾性收集近14年武汉市5家教学中心医院经结肠镜与病理诊断为UC的病例,统计患病情况、临床表现、内镜及病理特点以及诊断与预后。结果:近14年UC病例明显增多,呈上升趋势,但仍然是少见病。389例患者中,男女比1.53∶1,均龄42岁,平均病程3.7年。UC主要临床表现为腹泻(80.2%)、血便(75.1%)。肠外表现18例(4.6%),并发症35例(9.0%),较西方国家低。病变以初发型(40.6%)和反复发作型(44%)为主,轻中度病变多见(86.6%),部位以左半结肠炎为主(76.6%),绝大多数患者经氨基水杨酸类药物和糖皮质激素治疗有效(86%)。结论:近14年来武汉地区UC呈上升趋势,但仍是少见病。临床特点肠外表现和并发症少,病情较轻,经治疗预后较好,但诊断困难、易复发。
Objective: To investigate prevalence of ulcerative colitis (UC) in Wuhan city of China, and to summarise clinical and pathological characteristics of UC patients in the latest 14 years. Methods: 389 cases of UC were retrospectively collected from five central hospitals in Wuhan City from 1990 to 2003. Evaluation of the prevalence, clinical and pathological features, diagnosis and treatments was made. Results: The cases of UC were increasing during 1990~2003 in Wuhan city, but the estimated prevalence of UC was 0.8/100 000 in 2002, lower than that in western countries. Ratio of male to female was 1.53∶1. The mean age of UC at diagnosis was 42 years old. The mean duration of the disease was 3.7 years. Clinical manifestations were mainly diarrhea (80.2%) and bloody stool (75.1%), the extraintestinal manifestations and complications were less than those in western countries. Mild and moderate cases (86.6%) and left-sided colitis (76.6%) were remained dominant, and so did the first onset type and relapsed type in clinic. Conclusion: The prevalence of UC was increased in Wuhan during the latest 14 years, but not as high as in western countries. Features of UC cases were prevalent in middle age, short course of the disease, low occurrence of extra-intestinal manifestations and complications, relapse of the disease and better prognosis.
出处
《武汉大学学报（医学版）》
CAS
2005年第4期502-505,共4页
Medical Journal of Wuhan University
基金
国家自然科学基金资助项目(30470783)
