摘要
为探讨人体合用时羧苄青霉素（ＣＡＲ）对妥布霉素（ＴＯＢ）药物动力学的影响，本文进行了ＴＯＢ单用组与ＴＯＢ和ＣＡＲ合用组的试验，以微生物法检测ＴＯＢ血和尿中浓度，证明两组ＴＯＢ静脉恒速滴注均符合二房室模型，ＣＡＲ可使ＴＯＢ的Ｔ１／２延长１．２０ｈ，使ＴＯＢ２４ｈ尿回收率平均减少５３．１８％，显示ＣＡＲ对ＴＯＢ的药动学有明显的影响。
Abstract The experiment was carried out with two groups-the
tobramycin(TOB)and
combination group (TOB-CAR).There were 7 healthy volunteers in each group.The TOB
concentration in blood and urine was detected using mi-crobiological method with bacillus
pumilus. The results demonstrated that serum data fitted the two- compartmentopen model.The
half-life of TOB in combination with the CAR was prolonged for 1.2h and the average urinary
re-covery during 24h was decreased 53.18%by CAR. The conclusion could be drawn that CAR
has apparent effecton the pharmacokinetics of TOB in the healthy volunteers. Kev words
tobramycin,carbenicillin,pharmacokinetics
出处
《中国医院药学杂志》
CAS
CSCD
北大核心
1995年第11期485-487,共3页
Chinese Journal of Hospital Pharmacy
