摘要
目的制备氧化苦参碱缓释片剂,并评价其体外释药特性。方法以羟丙甲纤维素为缓释骨架材料,采用湿法制粒压片,制备氧化苦参碱缓释片,进行体外释放度实验,考察释放介质对释放度的影响。结果研制的氧化苦参碱缓释片具有明显的缓释作用,药物的体外释放符合一级动力学规律[ln(100-Q)=-0.11t+4.50,r=0.09998]。结论该缓释片处方合理,制备工艺简单,达到了预期结果。
OBJECTIVE To prepare oxymatrine sustained-release tablets and evaluate the drag release property.METHODS Oxyma-trine sustained-release tablets were prepared with HPMC by wetting granulating method. The release rates of the sustained-release tablets were determined and the effects of the release medium were investigated. RESULTS The prepared sustained-release tablets had an obvious sustained-release effect, and the drug release pattern folloloed the first order kinetics[ln(100- Q) =- 0.11t+4.50,r = 0.9998].CONCLUSION The sustained-release tablets reach the expectable results with its reasonable formulation and simple technology.
出处
《中国药学杂志》
CAS
CSCD
北大核心
2005年第13期1002-1004,共3页
Chinese Pharmaceutical Journal
