摘要
ＭｃＡｂＦ（ａｂ＇）_２免疫脂质体制备及其亲和性的放免测定刘健，陈正秋，刘汉芝，范启修，沈德诚，李树梅（中国医学科学院，中国协和医科大学，血液学研究所，天津３０００２０）脂质体作为药物载体可降低药物毒性，提高药效［１，２］。由ＭｃＡｂ制备的兔疫脂质体?..
Abstract The F(ab')2-DNR-liposomes were prepared using F(ab')2 obtained from digested monoclonal antibody against human white cells HI30(CD45).Their affinity constant for peripheral blood mononuclear cells was determined by radioimmunoassay. Ka=2.0×109 .A good specific conjugation ability was dernonstrated. In preparing the immunoliposomes,it was found that F(ab')2 coupled to the smaller liposomes with higher conjugation ratio.
出处
《中国医学科学院学报》
CAS
CSCD
北大核心
1995年第5期383-386,共4页
Acta Academiae Medicinae Sinicae
基金
国家自然科学基金
