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梗阻性不稳定膀胱模型的尿流动力学评价 被引量：1

Evaluation on urodynamics of the partial bladder outlet obstruction model
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摘要 目的:建立兔不全梗阻性不稳定膀胱动物模型,并观察其尿流动力学的变化。方法:取雄性成年新西兰大白兔30只,随机分为对照(假手术)组和梗阻组各15只。不全梗阻性手术后第8周,在氯胺酮和氟哌利多全麻下行尿流动力学等检侧。结果:梗阻8周后,梗阻组兔的膀胱尿流动力学主要参数较对照组有显著变化。梗阻组不稳定膀胱的发生率为60%。该膀胱出口不全梗阻动物模型无论从膀胱的病理或尿流动力学的改变,均与人类慢性膀胱出口不全梗阻类似。结论:这一动物模型的成功建立,为进一步研究人类慢性不全梗阻性不稳定膀胱疾病的病理、病理生理变化及治疗提供了一个平台。 Objective: To establish a rabbit unstable bladder and Partial Bladder Outlet Obstruction (BOO) model, and to study on urodynamic changes. Methods: 30 male New Zealand rabbits were divided into control group and operative group. After 8 weeks, urodynamic changes were determined after they were anaesthetized by ketamine and droperidol. Results: Prominent changes of Main urodynamic parameters were found between the operative group and control group. The incidence rate of unstable bladder was 60%. Conclusion: The method of establishing rabbit model of Partial BOO is successful. It provides a platform for the study on the changes of pathology and pathophysiology of human chronic partial BOO and treatment of this kind of diseases.
作者 龚隽 程文 高建平 张征宇 葛京平 周水根 周文泉 马宏青 魏武 薛松 徐振宇 王冬 许松
机构地区 南京大学医学院临床学院(南京军区南京总医院)泌尿外科
出处 《医学研究生学报》 CAS 2005年第7期603-605,共3页 Journal of Medical Postgraduates
基金 中国博士后科学基金资助项目(批准号:2002032189)
关键词 兔 膀胱出口不全梗阻 不稳定膀胱 尿流动力学 Rabbit Partial bladder outlet obstruction Unstable bladder Urodynamics
分类号 R694.2 [医药卫生—泌尿科学]
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参考文献10

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共引文献7

同被引文献7

  • 1程文,高建平,张征宇.梗阻性不稳定膀胱逼尿肌细胞内Ca^(2+)的变化及意义[J].医学研究生学报,2005,18(9):787-789. 被引量：3
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医学研究生学报
2005年 第7期

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