摘要
在自行设计的塔式氯化器中,以路易氏酸作催化剂,分子氯氯化对硝基氯苯合成1,2-二氯-4-硝基苯,根据该氯化过程特征,利用正交实验设计方法结合单因素实验考察了有关因素对氯化过程的影响,通过优化得到了最佳氯化工艺条件:m(催化剂)/m(对硝基氯苯)=5.5%～6.0%;氯气流量3.5～4.5 mL/s;温度95～100 ℃;时间6 h.在最佳工艺条件下,1,2-二氯-4-硝基苯的收率可达83.26%,并对实验结果进行了重复验证.
1,2-Dichloro-4-nitrobenzene was prepared by reaction of 1-chloro-4-nitrobenzene(PNCB) with chlorine in a specially designed tower chlorinator in the presence of Lewis acid catalyst.The optimum reaction conditions were:m(cat.)/m( PNCB)=5.5%～6.0%,flowrate of chlorine 3.5～4.5 mL/s,reaction temperature 95～100 ℃ and reaction time 6 h.The yield of 1,2-dichloro-4-nitrobenzene was 83.26%,higher than that acquired in a flask reactor.
出处
《精细化工》
EI
CAS
CSCD
北大核心
2005年第7期549-551,共3页
Fine Chemicals
