环氧合酶-2与卵巢癌
摘要
环氧合酶-2(COX-2)是人体内分解花生四烯酸合成各种前列腺素(PG)的一个重要限速酶。COX-2在正常组织中不表达或低表达,在炎症、分娩、恶性肿瘤等情况下表达上调。近年来研究发现其在卵巢癌组织中表达亦上调,并且在肿瘤浸润的前缘及转移灶中表达显著升高。COX-2高表达组的平均生存时间明显低于低表达组,而且高表达组对化疗的敏感性差。因而推断COX-2的高表达与卵巢癌的发生、发展、转移以及患者的预后和化疗耐药有关。选择性COX-2抑制剂在肿瘤治疗中有其可行性。
参考文献20
-
1Kulkarni S, Rader JS, Zhang F.et al. Cyclooxygenase-2 is overexpressed in human cervical cancer. Clin Cancer Res, 2001,7(2):429-434.
-
2Tong BJ ,Tan J, Tajeda L, et al. Heightened expression of cyclooxygenase-2 and peroxisome proliferator-activated receptor-delta in human endometfial adenocarcinoma. Neoplasia, 2000,2(6):483-490.
-
3Matsumoto Y, Ishiko O, Deguchi M, et al. Cyclooxygenase-2 expression in normal ovaries and epithelial ovarian neoplasms. Int J Mol Med, 2001,8(1):31-36.
-
4Subbaramaiah K, Chung W J, Dannenberg AJ. Ceramide regulates the transcription of cyclolxygenase-2. Evidence for involvement of extracellular signal-regulated kinase/c-Jun. N-terminal Kinase and P38 mitogen-activated protein kinase pathway. J Biol Chem, 1998,273(49):32943-32949.
-
5Shigemasa K, Tian X, Gu L, et al. Expression of cyclooxygenase-2 and its relationship to p53 accumulation in ovarian adenocarcinomas. Int J Oncol, 2003,22(1):99-105.
-
6Landen CN Jr, Mathur SP, Richardson MS, et al. Expression of cyclooxygenase-2 in cervical, endometrial, and ovarian malignancies. Am J Obstet Gynecol, 2003,188(5):1174-1176.
-
7Li S, Miner K, Fannin R, et al. Cyelooxygenase-1 and 2 in normal and malignant human ovarian epithelium. Gynecol Oncol, 2004,92(2):622-627.
-
8Denkert C, Kobel M, Pest S, et al. Expression of cyclooxygenase-2 is an indepemdent prognostic factor in human ovarian carcinoma. Am J Pathol,2002, 160(3): 893-903.
-
9Leahy KM,Omberg RL, Wang Y,et al.Cyclooxygenase-2 inhibition by celecoxib reduces proliferation and induces apoptosis in angiogenic endothelial cells in vivo. Cancer Res, 2002,62(3):625-631.
-
10Dohadwala M,Luo J,Zhu L,et al. Non-small cell lung cancer cyclooxygenase-2-dependent invasion is mediated by CD44.J Biol Chem, 2001.276(24):20809-20812.
-
1李莉,方国恩.环氧合酶-2与乳腺癌研究进展[J].国外医学（外科学分册）,2005,32(4):293-297. 被引量：1
-
2佟林林,王梅花,李佩玲.COX-2与妇科肿瘤[J].国际遗传学杂志,2006,29(6):437-440.
-
3钟彪,孙治君.环氧合酶-2与乳腺癌的研究进展[J].现代肿瘤医学,2011,19(2):386-388. 被引量：4
-
4邢丽华,张珍祥,徐永健.环氧化酶-2与肿瘤的研究进展[J].国外医学（生理病理科学与临床分册）,2003,23(4):371-373. 被引量：2
-
5周琴.卡莫司汀在体内分解成烷化剂后杀伤肿瘤细胞的作用机制分析[J].吉林医学,2012,33(21):4569-4569.
-
6刘锦,李贵新.COX-2与乳腺癌的发生发展[J].国际病理科学与临床杂志,2008,28(5):425-428. 被引量：2
-
7杨楠,冯义朝.环氧合酶与胃癌关系的研究进展[J].医学研究与教育,2013,30(5):83-86. 被引量：1
-
8张君红,林瑶光.血小板衍生生长因子受体和COX-2与胃癌研究进展[J].中国医药指南,2012,10(8):382-384.
-
9王天翔,王家富,柳雅玲.环氧化酶-2与胃癌的相关性研究[J].泰山医学院学报,2008,29(1):71-73.
-
10马杰,魏志平,刘彦群.环氧合酶2与皮肤肿瘤相关性的研究进展[J].医学综述,2009,15(20):3098-3100. 被引量：1
