摘要
按临床方法建立犬的深低温停循环手术模型，分别于４个时点取犬脑皮质和脑脊液标本进行研究。结果发现：与转流前相比，转流中、停循环６０ｍｉｎ及再灌注３０ｍｉｎ时，脑内能量代谢障碍及超微结构损伤均渐加重，术前用辅酶Ｑ１０组犬脑的能量代谢障碍及超微结构损伤均明显减轻。
The models of deep hypothermic circulatory arrest with cardiopulmonary bypass were made on 16 dogs. The cerebral cortex and cerebrospinal fluid (CSF) specimens were obtained for study at four time points. The results showed that when compared with the pre-CPB values and findings,intracerebral energy metabolic derangement and ultrastructural injuries became progressively worse during the course of CPB, 60 minutes of circulatory arrest and 30 minutes of reperfusion. But,in CoQ10 group the aforementioned changes were obviously milder.
出处
《中华胸心血管外科杂志》
CSCD
北大核心
1994年第2期165-166,T006,共2页
Chinese Journal of Thoracic and Cardiovascular Surgery
关键词
深低温停循环
脑
超微结构
辅酶
Deep hypothermic circulatory arrest
Brain
ATP
Ultrastructure
Co-enzyme Q_(10)
