摘要
对３０例喉癌伴颈淋巴结转移者进行ＤＮＡ图像分析和核仁组成区嗜银蛋白（ＡｇＮＯＲ）、癌胚抗原（ＣＥＡ）、雌激素受体（ＥＲ）测定。结果显示：原发灶和转移灶的ＤＮＡ含量（１３．８２３３，１２．２１４４），ＡｇＮｏＲ数目（１０．９７３，１１９７１），ＣＥＡ阳性率（７０％，７５％）及ＥＲ阳性率（７０％，４５％）均显著高于正常对照组。上述指标在原发灶和转移灶之间无明显差异（Ｐ＞０．０５）；生存期大于５年者ＤＮＡ含量、ＡｇＮＯＲ数目和转移灶ＣＥＡ阳性率显著低于生存期小于５年者，而转移灶ＥＲ阳性率在预后良好者显著高于预后差者。接受放疗者预后转好（Ｐ＜０．０５）。提示多项指标联合检测原发灶和转移灶对判断预后意义更大；对预后指标较差者应加强放疗。
The purpose of this study is to find out the biological feature of laryngeal caneer and metastatic lymph nodes with DNA Image Analysis,Argyrophilic Nucleolar Organizer Region (AgNOR), Carcinoembryonic Antigen (EA)and Estrogen Receptor(ER) 30 patients were included in this study.It was found that carcinomatous tissues showed a statistically significantly higher DNA con-tent,AgNOR content, and positive reaction of CEA and ER than those of nomal tissue(P<0.01), Paired comparisons were perfoimed in primary tumor and metastases and didn′t show statistical differ- ence(P>0.05).The group with survival time over 5 years had a significantly lower DNA content,AgNOR content,CEA positive reaction of metastases and higher ER positive reaction of metastases than those with less than 5 years survival(P<0.01).But there no was consistant relationship between primary tumor CEA or ER positive reaction and survival time(P>0. 05).The patients who accepted radiotheraphy had better prognosis than those who didn′t(P<0.05)The above results indicate that the combined analysis of metastases and primary tumor will provide a good feature for biological activity. In addition,radiotherapy before and after operation will be beneficial.
出处
《中华耳鼻咽喉科杂志》
CSCD
1994年第4期234-237,T041,共5页
Chinese Journal of Otorhinolaryngology
关键词
喉肿瘤
肿瘤转移
癌胚抗原
预后
Laryngeal neoplasms Neoplasm metastasis DNA,neoplasm Reeeptors,estrogen Carcinoembryonic antigen
