摘要
对20例外科治疗的重症肌无力病人,用光镜,电镜,免疫组化及计算机图像分析系统,定量观察其胸腺指突状细胞的超微结构和分布特征,结合临床随访发现,患者胸腺内指突状细胞与对照组比较无形态特征区别,但对S-100免疫组化染色均呈阳性反应,其数量在重症肌无力组增多(P<0.05),胸腺瘤伴重症肌无力组增多更明显(P<0.01);患者胸腺内S-100阳性细胞数量越多,对胸腺切除的疗效越差。认为胸腺内指突状细胞的数量增多在重症肌无力胸腺自身耐受机制障碍及患者临床预后中的作用不容忽视。
Optical , transmission electronic microscopy (TEM ) and quantitative im- munocytochemical technique were applied to investigate the interdigiting cells (IDC) in the thymuses from twenty patients of myas-thenia gravis (MG) with or without thymo-ma, comparing with age-mateched normal thymuses. It showed that there were no morphological difference in IDC between the group of MG and control groups other than the S-100 protein prostive. The number of IDC increased mostly in the MG (P<0. 05)
and the thymoma with MG (P<0. 01). The more S-100 positive cells, the worse clinical prognosis. These findings suggested that the increased IDC may affect on both mechanisms of the brokendown self-tolerance and clinical prognosis in MG.
出处
《临床与实验病理学杂志》
CAS
CSCD
北大核心
1994年第4期279-282,T004,共5页
Chinese Journal of Clinical and Experimental Pathology
关键词
重症肌无力
胸腺
指突状细胞
免疫形态学
myasthenia gravis
thymus
interdigitating cells
morphometry
image analysis
