摘要
用致癌剂二甲基苯丙蒽丙酮溶液诱导４０只金黄地鼠颊囊癌过程中动态观察微血管形态、机能和血液流变状况的变化。结果表明，癌变前病变区微血管无明显改变，肿瘤出现后病变区微血管排列紊乱、扭曲、不平整、无极向，数目减少，出现瘀血和血窦，血流速度减慢，流量减小等改变。微循环障碍随肿瘤生长而加重。肿瘤形成前后血液流变状态有明显差异，与微血管变化吻合。血液瘀滞度随癌肿生长而加剧。血液流变改变主要是因肿瘤生长过程中大分子物质增加，血细胞表面负电荷减少，从而聚集性增强。实验证明，肿瘤区微循环机能和微循环障碍互为因果关系。
A 0. 5% DMBA in acetone was painted on hamster cheek pouch three times a week, inducing mucosa squamous cell carcinoma. During the cancer formation, the authors were detected the figure and function of microcirculation and hemorheology. Before carcinoma apperance the microcirculation was unchangablenecs in the lesion aera. When the carcinoma appeared, the figure and function of microcirculation changed distinctly and circulation disturbance became worse and worse by the growth of cancer. The normal pouch micrangium were lucidum, ramification distinctly, thickness regular, orientation clearly and arborescent. The preinvasive carcinoma micrangium were arrangement confusion,torsion, thickness irregular and orientation unclearly. When there were invasive carcinoma the micrangium were few rarefaction. Vascular plexus stasis of blood, hemorrhagia and blood stagnation. On the other hand, the results displaced, there was not variation of blood viscosity and others indices of hemorheology before cheek pouch carceration and carcinoma could initiation the change to hemorheology during tumor development. Among those changes, the most dramatic chang was the sharp rise of blood viscosity caused by plasma fibrinogen increasing. Cancer could not make the total number of blood cell increasing. It was positive relation between the hemorheology indices changing leading to tumor and microcirculation obstruction degree. The authors discussed the factors which determines blood viscosity. They also preliminary posed that the mechanism of hemorheology indexes changing were leaded by cancer.
出处
《华西口腔医学杂志》
CAS
CSCD
北大核心
1994年第3期165-168,T009,共5页
West China Journal of Stomatology
