摘要
为了研究甾体激素对子宫内膜合成前列腺素（ＰＧＳ）的影响，采用雌二醇（Ｅ２）１０－８ｍｏｌ／Ｌ和孕酮（Ｐ４）１０－７ｍｏｌ／Ｌ培养增生晚期（ｎ＝７）和分泌晚期（ｎ＝５）子宫内膜的分离腺体和基质细胞。结果表明，Ｅ２１０－８／Ｌ和Ｅ２１０－８ｍｏｌ／Ｌ＋Ｐ４１Ｏ－７ｍｏｌ／Ｌ刺激增生晚期的子宫内膜腺体细胞产生ＰＧＦ２α明显增加，对分泌晚期子宫内膜腺体细胞以及增生晚期和分泌晚期子宫内膜基质细胞均无明显影响。ＰＧＥ２，水平不受甾体激素的影响。
The glandular cells and stromal cells from late proliferative endometrium(n=7) and latesecretory endometrium(n=5) were incubated with 10-8mol/ L E2, 10-7mol/ L P4 and 10-8mol/ L E2+1O-7mol / L P4 with an aim of studying the effect of steroid hormones on prostaglandins (PGS)re-leasing from endometrium. It was demostrated that 10-8mol / L E2 and 10-8mol / L E7+1O7mol / LP4 significantly increased PG F2α:output by primary cultures of glandular cells isolated from lateproliferative endometrium. No effects was found on stromal cells from late proliferative endometrium,and stromal and glandular cells from late secretory endometrium. 10-7mol / L P4 didn’t effect thePGF2α output on glandular and stromal cells isolated from late proliferative and late secretoryendometrium PGE2 was not affected by steroid hormones.The results indicate that endometrial glandsare targets for the E2-stimulated increase in PGF2α output by late proliferative endometrium.
出处
《生殖医学杂志》
CAS
1994年第2期110-113,共4页
Journal of Reproductive Medicine
关键词
子宫内膜
腺体
前列腺素类
雌二醇
孕酮
Endometrium Glandular Prostaglandins Estradiol Progesterone
