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影响成年齿状回神经干细胞增殖和分化的因素 被引量：2

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摘要 齿状回颗粒下区终生存在着神经干细胞,它们不断增殖、分化成神经元和神经胶质细胞,最终迁移到颗粒细胞层。神经干细胞在以上的动态归转过程中受到许多因素诸如激素、生长因子、神经递质、环境、行为、病变、毒物以及药物等的影响或调节。因此,揭示上述因素与神经干细胞增殖和分化的关系,对于阐明毒物的神经毒理、中枢神经系统退行性疾病和精神病的发病机制及其防治具有重要意义。
作者 林丹 邓祥发 郭灵
机构地区 广西医科大学人体解剖学教研室
出处 《解剖学研究》 CAS 2005年第2期144-147,共4页 Anatomy Research
基金 广西医科大学科研基金(No.504116)
关键词 影响因素 成年齿状回神经干细胞 增殖 分化 中枢神经系统退行性疾病 精神病 发病机制
分类号 R329.2 [医药卫生—人体解剖和组织胚胎学]
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参考文献25

  • 1Altman J, Dss GD. Autoradiographic and histological evidence of postnatal hippocampal neurogenesis in rats. J Comp Neurol, 1965,124:319～335.
  • 2Kornack DR, Pakic P. Continuation of neurogenesis in the hippocampus of the adult macaque monkey. PNAS,1999,96: 5768～5773.
  • 3Eriksson PS, Perfilieva E, Bjork-Eriksson T, et al.Neurogenesis in the adult human hippocampus. Nat Med,1998,4: 1313～1317.
  • 4Cameron HA, Wolley CS, McEwen BS, et al.Differentiation of newly born neurons and glia in the dentate gyrus of the adult rat. Neruoscience, 1993,56:337～344.
  • 5Drapeau E, Mayo W, Aurousseau C, et al. Spatial memory performaces of aged rats in the water maze predict levels of hippocampal neurogenesis. PNAS,2003, 100: 14385～14390.
  • 6Tanapat P, Hastings NB, Reees A J, et al. Estrogen stimulates a transient increase in the number of new neurons in the dentate gyrus of the adult female rat. J Neurosci, 1999,19: 5792～5801.
  • 7Cameron HA and Gould E. Adult neurogenesis is regulated by adrenal steroids in the dentate gyrus.Neuroscience, 1994,61: 203～209.
  • 8Cameron HA, Woolley CS, Gould E. Adrenal steroid receptor immunoreactivity in cells born in the adult rat dentate gyrus. Brain Res , 1993,611: 342～346.
  • 9Gould E, McEwen BS, Tanapat P, et al. Neurogenesis in the dentate gyrus of the adult tree shrew is regulated by psychosocial stress and NMDA receptor activation. J Neurosci, 1997,17: 2492～2498.
  • 10Madeira MD, Cadete-Leite A, Andrade JP, et al.Effects of hypothyroidism upon the granular layer of the dentate gyrus in male and female adult rats: a morphometric study. J Comp Neurol, 1991,314:171～186.

同被引文献27

  • 1刘平,戴冀斌.大鼠脑室下区神经干细胞的分离培养与分化[J].解剖学研究,2005,27(3):194-196. 被引量：1
  • 2杜宝玲,张伟,曾园山.皮肤干细胞将成为细胞治疗神经系统疾病的新的细胞来源[J].解剖学研究,2006,28(3):226-228. 被引量：1
  • 3Asayama K, Yamadera H, Ito T, et al. Double blind study of melatonin effects on the sleep-wake rhythm,cognitive and non-cognitive functions in Alzheimer type dementia, J Nippon Med Sch, 2003,70: 334～341.
  • 4Kim M J, Kim HK, Kim BS, et al. Melatonin increases cell proliferation in the dentate gyrus of maternally separated rats. J Pineal Res, 2004,37:193～197.
  • 5Fukuda K, Morioka H, Imajou S, et al. Structurefunction relationship of the eukaryotic DNA replication factor, proliferating cell nuclear antigen. J Biol Chem,1995,270: 22527～22534.
  • 6Ino H, Chiba T. Expression of proliferating cell nuclear antigen (PCNA) in the adult and developing mouse nervous system. Brain Res Mol Brain Res, 2000,78:163～174.
  • 7Curtis MA, Pennery EB, Pearson J, et al. The distribution of progenitor cells in the subependymal layer of the lateral ventricle in the normal and Huntington's disease human brain. Neuroscience, 2005,132:777～788.
  • 8Alvarez-Buyllal A, Garcia-Verdugo JM. Neurogenesis in adult subventricular zone. J Neurosci, 2002,22: 629～634.
  • 9Komack DR, Rakic P. Continuation of neurogenesis in the hippocampus of the adult macaque monkey. Proc Natl Acad Sci USA, 1999,96:5768～5773.
  • 10Niles LP, Armstrong KJ, Rincon Castro LM, et al.Neural stem cells express melatonin receptors and neurrotrophic factors: colocalization of the MT1 receptor with neuronal and glial markers. BMC Neurosci, 2004,5,41～49.

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解剖学研究
2005年 第2期

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