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环氧化酶-2在人肺癌组织中的表达及意义 被引量：1

The expression of cyclooxygenase-2 and its significance in human lung cancer tissue.
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摘要 目的近期发现环氧化酶-2(cyclooxygenase-2,COX-2)在肺癌组织中有高表达且对该疾病的预后有重要影响。为阐明这一问题,对COX-2在人肺癌组织中的表达及作用进行了研究。方法运用组织芯片技术制成126例肺癌组织芯片,采用免疫组化方法对标本中COX-2的表达进行检测,并对COX-2的表达情况与疾病生物学特点、患者生存时间等关系进行了回顾性队列研究。结果COX-2阳性表达86例(68.25%)。COX-2在肿瘤中的表达与肿瘤T分期、N分期及疾病临床分期等肿瘤部分生物学特性有相关性(P<0.05)。结论COX-2在人肺癌组织中有高表达,其表达能作为患者生存时间预测的单因素影响因子,成为外科手术切除后的肺癌病例预后较差的标志。 Objective Elevated expression of cyclooxygenase-2 (COX-2) has been found to be a feature of lung cancer recently. To clarify these issues , we studied the expression of COX-2 in tissues of patients with lung cancer .Methods Expression of COX-2 in specimens of 126 lung cancer patients were evaluated by tissue chip and immunohistochemical methods. The relationships between COX-2 expression,survival time and the biology behavior of lung cancer were analyzed by retrospective cohort study. Results Expression of COX-2 was positive in 86 cases (68.25%). The correlation between COX-2 expression and some biology behaviors of lung cancer(T stage、N stage and clinical stage)was significant in statistics(P<0.05). Conclusion Expression of COX-2 is detected in lung cancer tissue. It is suggested to be an independent predictor of survival in survival analysis and it is significant poor prognostic factor in the surgically resected lung cancer.
作者 李灿 张伟 李小飞 齐海妮 朱以芳 卢强
机构地区 第四军医大学唐都医院胸外科 第四军医大学唐都医院病理科
出处 《现代肿瘤医学》 CAS 2005年第3期345-348,共4页 Journal of Modern Oncology
关键词 肺癌 环氧化酶 生存分析 lung cancer cyclooxygenase-2 (COX-2) survival analysis
分类号 R734.2 [医药卫生—肿瘤] R730.2 [医药卫生—肿瘤]
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共引文献17

同被引文献11

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现代肿瘤医学
2005年 第3期

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