摘要
目的研究survivin基因在非小细胞肺癌(NSCLC)中的表达及其临床意义。方法用免疫组化(S-P法)染色技术对76例NSCLC组织和12例癌旁正常肺组织标本进行survivin基因表达的检测和分析。结果NSCLC组织中survivin的阳性表达率为59.2%,而癌旁正常肺组织无1例表达。survivin的表达与NSCLC细胞分化程度、复发和预后有密切关系(P<0.05)。但与年龄、性别、吸烟、病理类型、肿瘤大小、淋巴结转移及TNM分期无明显相关(P>0.05)。结论survivin基因与NSCLC的发生发展有关,其过度表达提示NSCLC预后不良;Survivin基因有望成为肺癌诊断和基因治疗的新靶点。
Objective To investigate the expression and significance of survivin in non-small cell lung cancer (NSCLC). Methods The expression of survivin was examined in 76 patients with NSCLC and in 12 patients with normal lung tissues nearby by immunohistochemical methods (S-P). Results The positive rate of survivin in NSCLC was 59.2%, and survivin was not expressed at adjacent normal lung tissues. The positive expression of survivin was associated with cell differentiation, recurrence and prognosis (P<0.05), but not associated with ages, gender, smoking, histological classification, the tumor size, TNM stages and lymph node involvement (P>0.05). Conclusion There is close relationship between survivin and NSCLC; the over-expression of survivin suggests the bad prognosis in NSCLC Survivin gene may be identified as a defining diagnostic marker and a potential therapeutic target in NSCLC.
出处
《现代肿瘤医学》
CAS
2005年第3期338-340,共3页
Journal of Modern Oncology
