摘要
目的观察和评价纳洛酮救治新生儿重度窒息的疗效。方法采用前瞻性研究方法,分析89例重度窒息新生儿,在常规复苏处理基础上,治疗组36例加用纳洛酮,余53例为对照组。比较两组复苏后在5min和10min后Apgar评分差异、抢救成功率和缺氧缺血性脑病(hypoxicischemicencephalopathy,HIE)、颅内出血(intracranialhemorrhage,ICH)等并发症的发生率。结果治疗组在5min和10min时Apgar再评分均值都明显高于对照组(P均<0.05)。5min时治疗组抢救成功率也明显高于对照组(P<0.05)。治疗组的HIE和ICH等并发症的发生率低于对照组,但尚无统计学的差异。结论纳洛酮能拮抗β内啡肽,减轻颅脑损伤,提高复苏效果,是窒息复苏中使用的可靠药物,可以降低窒息后造成的颅脑损伤,并有可能有效避免由于窒息而造成的颅脑损伤等后遗症。
Objective To observe and assess the effects of naloxone in treating serious neonatal asphyxia.Methods By using a perspective research method,analyses were made on 89 serious cases of neonatal asphyxia.36 infants in naloxone-treated group were treated with naloxone on the basis of normal resuscitating treatment, while the rest made up of the asphyxia control group who were treated without using naloxone.A comparison was made between the two groups on the differences in the Apgar grades of 5 min and 10 min after resuscitation, success rates of first aid, and the occurrence rate of complications such as hypoxic-ischemic encephalopathy (HIE) and intracranial hemorrhage (ICH).Results The Apgar grades of 5min and 10 min of the naloxone-treated group were obviously higher than those of the control group (P<0.05).The success rate of first aid of 5 min of the naloxone-treated group was also obviously higher than that of the control group (P<0.05).The occurrence rate of complications such as ICH and HIE of the naloxone-treated group was lower than that of the control group, but there was no statistical difference between the two groups.Conclusion Naloxone could reduce plasma β-endorphin,alleviate encephalic damages resulting from asphyxia and enhance the effects of resuscitation, and therefore is a safe medication to resuscitate asphyxiated neonates.
出处
《同济大学学报（医学版）》
CAS
2005年第3期66-68,共3页
Journal of Tongji University(Medical Science)
