摘要
目的探讨肺原发性恶性纤维组织细胞瘤的病理组织学特点,为临床和病理早期诊断提供依据。方法应用光镜和免疫组化方法对5例肺恶性纤维组织细胞瘤手术切除标本进行组织学观察。结果肺组织被瘤样纤维细胞和组织细胞替代,细胞异型性明显,排列呈车辐状,其中可见散在性多核瘤巨细胞,所有病例组织EMA、CKpan、Desmin和S100均表达阴性。肿瘤细胞Vimentin及CD68均表达阳性。结论诊断肺原发性恶性纤维组织细胞瘤,需排除其他处恶性纤维组织细胞瘤,并结合临床表现和形态学及免疫组化标记综合考虑。
Objective To study histopathological characteristics of primary lung malignant fibrous histiocytoma and to discuss the diagnostic criterion of primary lung malignant fibrous histiocytoma Methods Five cases of primary lung malignant fibrous histiocytoma were studied by light microscope and immunohistochemistry Result Microscopic findings showed that the tumor consisted of diffuse neoplastic histiocytes and spindle-shaped fibroblasts arranged in a prominent storiform pattern intermingled with numerous multinucleared tumor giant cells Tumor cells were positive for Vimentin and CD68, but negative for EMA、S-100 and Desmin Conclusion Involvement of malignant fibrous histiocytoma elsewhere should be excluded first before making the diagnosis of primary lung malignant fibrous histiocytoma To confirm the diagnosis all the clinical manifestation、morphological characteristics and immunohistochemical detection all should be taken into account
出处
《河南肿瘤学杂志》
2005年第3期204-205,F002,共3页
Henan Journal of Oncology
关键词
肺原发恶性纤维组织细胞瘤
诊断标准
临床病理特征
primary lung malignant fibrous histiocytoma
diagnosis criteria
clinicopathological feature
