摘要
目的探讨nm23-H1基因产物的表达与鼻咽癌早发转移的关系。方法应用免疫组化S-P法对95例鼻咽癌组织蜡块进行nm23-H1检测。结果nm23-H1的阳性表达率为47.4%(45/95),早发转移组nm23-H1阳性率(26.7%)低于无转移组(60.0%),差异有统计学意义(P<0.05)。nm23-H1表达与临床分期无关。结论nm23-H1阴性表达与鼻咽癌早发转移有关,nm23-H1的表达水平可能是预测中晚期鼻咽癌远处转移的一个重要的生物学指标。
Objective To study the relationship between the expression of nm23- H1 gene product and early distant metastases in nasopharyngeal carcinoma (NPC). Methods The S- P immunohistochemical method was used to detect the expression of nm23- H1 in 95 cases of NPC. Results The positive rate of nm23- H1 was 47.4 % (45/95). The positive rate of nm23- H1 in early distant metastases group (26.7 %) was much lower than those without distant metastases group (60.0 %) (P <0.05). The expression of nm23- H1 has no relation with clinical stage. Conclusions The negative expression of nm23- H1 was relative to the early distant metastases. The expression levels of nm23- H1 gene may be an important biological indicator for predicting distant metastases in middle to advanced NPC.
出处
《肿瘤研究与临床》
CAS
2005年第3期173-174,共2页
Cancer Research and Clinic
