期刊文献+
任意字段
题名或关键词
题名
关键词
文摘
作者
第一作者
机构
刊名
分类号
参考文献
作者简介
基金资助
栏目信息

eNOS mRNA在无排卵型功血患者子宫内膜的表达与意义

Expression and significance of eNOS mRNA in endometrium of anovulatory functional bleeding
暂未订购
导出
摘要 目的观察无排卵型功血患者子宫内膜eNOSmRNA表达情况,探讨eNOS在无排卵型功血发病中的作用。方法RT-PCR技术检测10例正常子宫内膜和36例无排卵型功血患者子宫内膜eNOSmRNA的表达情况。结果人子宫内膜表达eNOSmRNA,无排卵功血患者的单纯增生和复合增生组子宫内膜的eNOSmRNA表达水平高于对照组(P<0.05)。结论eNOS表达上调可能参与无排卵型功血的发生发展。 Objective To investigate the expression of eNOS mRNA in the endometrium of patients with anovulatory functional bleeding. Methods RT-PCR was used to study the expression of eNOS mRNA in 10 normal endometrium and 36 endometrium of anovulatory functional bleeding. Results eNOS mRNA was expressed in human endometrium. The expression of eNOS mRNA was higher in the endometrium of simple hyperplasia and complex hyperplasis than those in normal endometrium. Conclusion eNOS were involved in pathagenesis of anovualatory functional bleeding.
作者 林坦 朱凤川
机构地区 福建省立医院妇产科 福建医科大学附属第一医院
出处 《山西医科大学学报》 CAS 2005年第3期348-350,共3页 Journal of Shanxi Medical University
关键词 子宫出血 子宫内膜 一氧化氮合酶 uterine hemorrhage endometrium nitric oxide synthase
分类号 R711.52 [医药卫生—妇产科学]
  • 相关文献

参考文献10

  • 1Salmonsen LA, Kovacs GT, Findlay JK. Current concepts of the mechanisms of menstruation [ J ]. Baillieres Best Pract Res Clin Obstet Gynaecol, 1999,13(2): 161 ～179.
  • 2An Buren GA, Yang DA, Clark KE. Estrogen-induced uterine vasodilatation is antagonized by L-arginine methyl ester, an inhibitor of nitric oxide synthesis [ J ]. Am J Obstet Gynecol,1992,167:828～833.
  • 3Ramsay B, De Belder A, Campbell S, et al. A nitric oxide donor improves uterine artery diastolic blood flow in normal early pergnancy and in women at high risk of preeclampsia [J ].Eur J Clin Invest, 1994,24: 76～ 78.
  • 4Zhang RS, Guth PH, Scremin OU, et al. Regulation of endometrial blood flow in ovariectomized rats: assessment of the role of nitric oxide [J]. Am J Obstet Gynecol, 1997, 273:H2009～ H2017.
  • 5Hurskainen R, Teperi J, Paavonmen J, et al. Menorrhagia and uterine artery blood flow[J ]. Hum Reprod, 1999,14( 1 ): 186～189.
  • 6Laudanski P, Anchim T, Wolczynski S. The role of nitric oxide in carcinogenesis and progression of neoplastic processes [ J ].Ginekol Pol, 2001,72 (4): 251 ～ 260.
  • 7Li Hsin-yang, Chang Sheng-ping, Yuan Chiou-chung, et al.Nitric oxide induce intensive apoptosis in indometrial epithelial cells in the presence of progesterone: involvement of mitogenactivated protein kinase pathways[J]. Mol Hum Reprod,2001,7(8) :755～763.
  • 8Hampton AL, Salamonsen LA. Endometrial expression of messenger ribonucleic acid encoding matrix metalloproteinases and their tissue inhibitors coincides with menstruation [ J ]. J Endocrinol, 1994,141 :R1 ～R3.
  • 9Marbaix E, Kokorine I, Henriet P, et al. The expression of interstitial collagenase in human endometrium is controlled by progesterone and by oestradiol and is related to menstruation [J]. Biochem J, 1995,305:1027～1030.
  • 10Hulboy DL, Rudolph LA, Matrisian LM, et al. Matrix metalloproteinase as mediators of reproductive function[J]. Mol Hum Reprod, 1997,3(1) :27～31.
山西医科大学学报
2005年 第3期

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部