摘要
目的观察低剂量5-Fu持续静点加草酸铂为主联合化疗对老年胃癌治疗的近期疗效.方法34例老年胃癌,低分化腺癌8例,中分化腺癌14例,黏液腺癌10例,印戒细胞癌2例,KPS评分≥70分,预计生存期＞3月,所有病人均行锁骨下静脉穿刺置管,化疗方案,草酸铂130 mg/m2,单次量最大不超过200 mg,第1天静脉滴注;亚叶酸钙200 mg,第1～5天静脉滴注,5-Fu 300 mg/(m2·d),采用便携式输液泵(百特泵)持续静点120 h,速度5 ml/h,21 d为1周期,3周期后评价疗效.结果完全缓解(CR)1例,部分缓解(PR)15例,无变化(NC)13例,进展(PD)5例,总有效率CR+PR 47.1%(16/34),治疗后癌胚抗原(CEA)、CA-199均有明显下降,与治疗前相比CA-199 P＜0.05;CEA P＜0.01,有显著差异.结论低剂量5-Fu持续静点加草酸铂为主联合化疗对老年胃癌治疗疗效满意,毒性反应发生低且轻微.
Objective To observe the short-term effect of combined low dose 5-Fu continuous infusion and L-OHP on elderly patients with gastric carcinoma. Methods Thirty-four elderly patients with gastric carcinoma were diagnosed by pathology and cytology, including 8 patients with poorly differentiated adenocarcinoma, 14 with well differentiated adenocarcinoma, 10 with mucous adenocarcinoma, and 2 with signet-ring cell carcinoma (KPS≥70). The anticipated survival lasted beyond 3 months. Subclavian veins were punctured during the treatment of all patients. Chemotherapeutic scheme was as follows: L-OHP 130 mg/m2 (single times dose ≤200 mg), iv infusion 2 h, on first day; CF: 200 mg, iv infusion from first to fifth day; 5-Fu: continous iv infusion for 120 h with infusion pump(at 5 ml/h). Every cycle lasted 3 weeks. The effect was evaluated after 3 cycles. Results Among 34 patients, 1 was achieved complete remission (CR), 15 partial remission (PR), 13 no change (NC); and 5 progressive diseases (PD). Total effective rate (CR+PR) were 47.1%(16/34). CEA and CA-199 were significantly reduced after treatment. And there was significantly statistical difference between pre and post-treatments (CEA P<0.05,CA-199 P<0.01). Conclusion The effect of combination of low dose 5-Fu infused continuously and L-OHP is satisfactory and side effects in the treatment is well tolerated.
出处
《山西医科大学学报》
CAS
2005年第3期327-328,共2页
Journal of Shanxi Medical University
关键词
胃肿瘤
草酸类
氟尿嘧啶
老年人
药物疗法
联合
stomach neoplasms
oxalic acids
fluorouracil
aged
drug therapy, combination
